Hello

[Caroline]

Indeed if the next step is biologics than you are speaking of 20.000 a year, but there is one cheaper step in between, the DMF's, about 2.000 a year, so tenfold cheaper, 70% chance of positive result and relatively harmless compared with the others as long as you keep a careful view on your lymphocytes.
If that did not work you can try other biologics. As far as I have a view on this forum, stelara is the most obvious one, ask Fred. Then there are also the range of ....MAB's, the monoclonal antibodies.

So there is still a long horizon, which hopefully you do not have to reach.

Caroline