Skyrizi vs Fumaderm for psoriasis

[Kat]

Agreeing with your statement Jim. I would also like to see the comparison over 8 years.

Calling Fumaderm: fumaric acid esters, is exactly right.
Fumaderm is a combination of MEF and DMF. The reason that MEF is added is because it speeds up a little the effect of the DMF, but on the other side it is so toxic that you cannot go above 6x120 mg. It is mainly dangerous for the Kidneys.

Second point.. Fumaderm is nowadays hardly used, it has been replace by the registered medication of Skilarence. Which is only DMF and does not have the drawback of the toxic element. So the research is pointing a little bit next to the target.

Third point: Skirizi is a immuno suppressor of a certain cytokine, it is not a medicine in the healing sense.
DMF/Fumaderm adds a surplus of fumarate into your body. The effect is that the citric-acid cycle in the cells will start working better and will reduce the waste that is produced by the cells where the cycle does not work correctly. This waste causes a series of effects in the body that leads to Psoriasis or Psoriatic Arthritis. So DMF is medication that is closer to “healing”. It does not heal in the sense that it repairs the problem, but it controls the problem.

I concede that you all know more about this than I do! But a question. Would an immune suppressor (doesn't alot/all of the biologics fit this category?) also control the problem if it worked for the person? Just asking as in what you mean with the wording "controls the problem" I do understand that one targets the immune system and I understand you are saying that DMF/Fumaderm works on the cells. But if they both work do they not both control the problem? Just trying to understand.