Psoriasis and bullous pemphigoid study

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This study looked at psoriasis patients and bullous pemphigoid (BP) a rare skin condition that causes itching, redness and blisters.

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Background:
Although the association of bullous pemphigoid (BP) and psoriasis is well‐established, the clinical and immunological features of patients with coexisting BP and psoriasis are yet to be investigated.

Objective:
We aimed to estimate the prevalence of psoriasis among patients with BP and to elucidate the clinical and immunological characteristics of BP patients with comorbid psoriasis.

Methods:
A retrospective cohort study including all consecutive patients diagnosed with BP throughout the years 2009‐2019 in a tertiary referral center.

Results:
The study encompassed 273 patients with BP, of whom 11 (4.0%; 95% CI, 2.3‐7.1%) had comorbid psoriasis. The onset of psoriasis preceded that of BP in 81.8% of patients by a median (range) latency of 26.5 (5.0‐34.0) years. Compared to BP patients without psoriasis, those with BP and comorbid psoriasis were significantly younger at the onset of BP (71.8 [9.3] vs. 79.4 [9.8] years; P=0.023), had a milder erosive phenotype (erosion/blister BPDAI mean [SD] score; 5 [4.1] vs. 22.3 [15.2]; P=0.025), lower levels of anti‐BP180 NC16A serum autoantibodies (236.6 [266.3] vs. 556.2 [1323.6] U/ml; P=0.008) as well as a higher prevalence of isolated linear C3 deposits (36.4% vs. 14.1%; P=0.043) and a lower prevalence of linear immunoglobulin G deposits (36.4% vs. 68.7%; P=0.025) along the dermal‐epidermal junction by direct immunofluorescence microscopy.

Conclusions:
Patients with BP and comorbid psoriasis present at a younger age with milder erosive phenotype and lower levels of pathogenic autoantibodies.

Source: onlinelibrary.wiley.com

*Early view funding unknown.