Health Boards
Wed-06-05-2020, 17:41 PM
Well Kat... that is what right is the point about, no knowledge.
I know that they are treating MS with Tecfidera.
The Max dose they are using is two pills 240mg a day, which is less than Jim.
BUT..... i know they have a wrong building up scheme, they are going much too fast, that is why one of the side effects is PML a braindisease, which is NOT caused by the DMF, but by the too low lymphocytes because of the too fast buildup. And, not to exclude, maybe because of the type of disease that MS is. It could be that the reaction to DMF is stronger that with Psoriasis.... but the build up is too fast.
Indeed I see all kinds of reports of liver disease with Tecfidera. But....what is the real cause? As we over here with 35 years of history, hardly have any liver problems. Is it so that the liver is already damaged by the MS?
The funny thing is... in the leaflet of Skilarence (this is not off topic..
) It says that is may cause liver and kidney problems. But did you know that they did not test that.. ? 
They took it over from other leaflets and historical data. And lots of that information is coming from the use of ... Fumaderm.
And yes, I fully agree that Fumaderm may have caused liver and kidney problems, because it contained a toxic part called MEF. This has all been investigated by Nicolle Litjens in her promotion. (Real Science)
But plain DMF... minor problems over here.
I hope Almiral is keeping records on how Skilarence is doing in practice and build up some historical knowledge that can get rid of the “believe”, “seems” and “I heard that”, and give clean numbers.
There are too much rumours going around on this medication.
I know that they are treating MS with Tecfidera.
The Max dose they are using is two pills 240mg a day, which is less than Jim.
BUT..... i know they have a wrong building up scheme, they are going much too fast, that is why one of the side effects is PML a braindisease, which is NOT caused by the DMF, but by the too low lymphocytes because of the too fast buildup. And, not to exclude, maybe because of the type of disease that MS is. It could be that the reaction to DMF is stronger that with Psoriasis.... but the build up is too fast.
Indeed I see all kinds of reports of liver disease with Tecfidera. But....what is the real cause? As we over here with 35 years of history, hardly have any liver problems. Is it so that the liver is already damaged by the MS?
The funny thing is... in the leaflet of Skilarence (this is not off topic..
) It says that is may cause liver and kidney problems. But did you know that they did not test that.. ? They took it over from other leaflets and historical data. And lots of that information is coming from the use of ... Fumaderm. And yes, I fully agree that Fumaderm may have caused liver and kidney problems, because it contained a toxic part called MEF. This has all been investigated by Nicolle Litjens in her promotion. (Real Science)
But plain DMF... minor problems over here.
I hope Almiral is keeping records on how Skilarence is doing in practice and build up some historical knowledge that can get rid of the “believe”, “seems” and “I heard that”, and give clean numbers.
There are too much rumours going around on this medication.