DMF (dimethylfumarate) quality of life study

[Caroline]

Thanks for showing this to us Fred.

A few remarks.

1. 8 weeks is far too less to measure full DMF capacity, that may take at least twice as long. 
   
2. Why the max of 720 mg? There is no reason for that, other than an imaginary reason caused by Fumaderm. In the Netherlands doctors experience shows that doses up to 1200 mg may be necessary to start up the working of the DMF, often afterwards this can be reduced again. 
   
3. What are the other FAE’s? Probably a combination of MEF and DMF, as in Fumaderm, as there are not much more possibilities, no one as far as I know. In 2004 a study of Nicole Litjens already showed that MEF is useless. Result, as in no difference concerning both medications was to be expected. Still only DMF is to be preferred. The addition of MEF has no value and makes the product toxic. 
   
4. They should have incorporated a controlled (slow) release version as that makes difference for half of the patients. 
   

I would not be surprised as the funding would have been given by Almirall