Psoriasis is associated with long‐term risk for overall malignancy in Koreans

[Fred]

This study looked at the long term risk of malignancy in Korean adult patients with psoriasis.

Quote:

---

Background:
The association between psoriasis and risk of malignancy has not been thoroughly evaluated in a large longitudinal cohort of Asian population.

Objective:
To determine the long‐term risk of malignancy in Korean adult patients with psoriasis.

Methods:
We conducted a nationwide population‐based prospective cohort study with a 15‐year observational period. During the baseline period (1997‐2000), total 1,773,786 Korean subjects who received health insurance from the National Health Insurance System were enrolled and 5,788 subjects were defined as a psoriasis group. The number of new‐onset malignancy was collected during the observational period (2001‐2015).

Results:
Patients with psoriasis had a higher adjusted hazard ratio (aHR) for development of overall malignancy (aHR 1.08, 95% confidence interval [CI] 1.00‐1.18) and gastric cancer (aHR 1.31, 95% CI 1.08‐1.58) compared to controls. The risks of non‐Hodgkin lymphoma and non‐melanoma skin cancer were significantly increased only in patients with psoriasis who received systemic treatments (aHR 2.86, 95% CI 1.07‐7.61 and aHR 3.93, 95% CI 1.47‐10.47, respectively).

Conclusion:
Psoriasis is associated with long‐term risk for overall malignancy in Koreans, which was primarily driven by the increased risk of gastric cancer.

Source: onlinelibrary.wiley.com

*Early view funding unknown