Hello from wooleyb

[Caroline]

Hi Caroline 

Thank you very much for your welcome and again for reading my ramble!!  It's not something I do often but it felt good to get my frustration out there so thanks for your kind words. 

I should fit into the club very then well if most members are more or less insane   Ah Fred, well as a newbie i can only believe what he tells me (for now lol) I guess!! 


As for my PPP, I completely agree with what you are saying, they are already talking to me about a drug called Acitretin and have given me a leaflet on it, so fully expect to be given that at some point in the near future...... Because I have PPP, the hospital have also asked me to consider going on a trial drug/placebo in January, it is called the APRICOT trial but to be honest as this is all new to me at the moment, I will revisit again in January and decide then.....

Thanks again Caroline 

Hi Wooleyb,

I like that you have a good feeling about the forum and its inhabitants, , it's very nice to have you here.

Acetretin is a known one. There are several members who have tried it or who are on it.

The apricot trail however might be something interesting. I have read something about it, and it is an Il-1 inhibitor.
On other places on the net, I find the following:

Quote:

---

Cytokines of the interleukin-1 (IL-1) family, such as IL-1α/β and IL-18, have important functions in host defense, immune regulation, and inflammation. Insight into their biological functions has led to novel therapeutic approaches to treat human inflammatory diseases.

So I think that is interesting. It is a different inhibitor than most other biologicals or systemics, e.g. Acetretin does not aim for this IL-1, DMF however does.

Our body contains very complex chemical reactions. And our immune system circles around all kinds of cytokines, interleukins, T-helper cells, pathways, and more. It is so complex that to investigate one tiny reaction they need a whole study.
But on the average we have an idea of the triggers of Psoriasis, which still means that we do not know the cause of why these triggers are activated.
What medicine gradually can do is reduce the triggers and so reduce the psoriasis. They still cannot take away the cause....


Caroline