Bill's pure dimethylfumarate thread

[Caroline]

Hi Caroline,

There is a comparative study on the effects of DMF and MEF, <Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro>. MEF does not seem to deplete GSH, so l-cysteine may not help, but I dont know. There are reports of liver toxicity with Tecfidera, so DMF can be hepatotoxic on its own, but whether l-cysteine supplementation can prevent this is speculative. All I know is that it makes it much easier for me to take DMF.

Cheers,

Bill

Yes, I have heard of this liver toxity of Tecfidera. But in all patients in the Netherlands, that are thousands, who have used Psorinovo, there was never a sign of liver problems as far as I can remember. But to be sure I will ask my doctor, I am going to see him anyway coming week or the week thereafter.

Cheers,
Caroline