Bill's pure dimethylfumarate thread

[Bill]

Hi Caroline,

There is a comparative study on the effects of DMF and MEF, <Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro>. MEF does not seem to deplete GSH, so l-cysteine may not help, but I dont know. There are reports of liver toxicity with Tecfidera, so DMF can be hepatotoxic on its own, but whether l-cysteine supplementation can prevent this is speculative. All I know is that it makes it much easier for me to take DMF.

Cheers,

Bill