Tue-07-03-2017, 14:02 PM
(Tue-07-03-2017, 08:30 AM)Caroline Wrote: There is quite a difference between Stelara and Taltz.
Stelara binds on interleukin (IL)-12 and IL-23 and Taltz binds on IL-17A, just like Cosentyx.
As we already see the very positive results of Cosentyx, reported here on the forum, it does make sense that Taltz is also doing well.
IL-17A is a protein, that plays a role in the inflammation, as well as IL-12 and IL-23 are chemicals produced by cells that stimulate inflammation.
Moderating or inhibiting these substances will have effect on the expression of the psoriasis.
That is a good point as they do target different IL's, but I suppose they had to test it against Stelara as it is the best performer and it's competition "Coesentyx" is still a new kid on the block itself.