Fumaderm and nausea

[Caroline]

Hey thank you all for all the information and advices,I had another horiible day and night with very bad nausea and vomiting even I reduced my dose to 3  yesterday,today I have not take any yet and I am still sick.Is it possible even that I haven't took a Pill today to feel like this,is that because it build up in my body?

I think it's unlikely as the DMF breaks down (I believe) in your intestines and converts to something harmless, but caroline knows the process of how the DMF works ...so I hope she comes and can explain better than me

DMF breaks quite quickly down in the intestines into MMF, monomethylfumarate. This is the real working substance. Fumarates are an essential part of the energy cycle of your cells. See the picture of the citric acid cycle.



It has an extremely diverse working in your body, lots of research has been done and more is being conducted and it appears that it has more and more possibilities then we ever expected. For Psoriasis it has several effects in modulating certain substances and regulating cells, which is why it is working.
But ... DMF is irritating for your intestines. This may and will cause your nausea. I recognise that.
The form of DMF I used, is as I told earlier a slow release version. It takes longer and spreads better in the intestines which is why they are less irritated than with Fumaderm.
The nausea, yes, it is there, and what I did was to ignore it. Just refusing to feel sick. And that worked, because I could say to myself: "you are not really sick, it is just the pills."