Fumaderm Safety

[jiml]

Hi Jim,

I was replacing the timing belt on my Fiat when you posted this. The lack of FDA approval relates to fumaric esters for psoriasis, not rrms. The concern about lymphopaenia seems overblown as the risk is very small, you need to have it  for at least six months, and there are symptoms of lymphopaenia like fatigue and susceptibility to colds which dont require a blood test. There is some uncertainty about low grade damage, hence your MRI scan and my agreement with you of the prudence of maintaining a high count. What I find out about the lymphocyte count and sun exposure might prompt further comment.

Cheers,

Bill

Hope you've got your fiat back on the road again, and timed right Bill

I think you are replying to this RE: Jim's journal
Yes you we right it's been blown out of proportion as there are far more cases of PML related to other drugs used for the treatment of psoriasis and psoriatic arthritis. The risks are low but nevertheless I think anything they offer by way of screening is fine by me.

Yes in all the cases I've read the monitoring was poor unlike mine which is slightly more than needed