Calcipotriol & betamethasone well tolerated for scalp psoriasis in adolescents.

[Fred]

Though not mentioning the products by name in the study I assume it is about treating adolescent scalp psoriasis with Dovobet (Daivobet) and Dovonex (Daivonex) as it was sponsored by LEO Pharma.

Quote:

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Objectives:
The primary objective was to assess the safety of once-daily application of fixed-combination calcipotriol plus betamethasone dipropionate gel in adolescent scalp psoriasis. Assessment of efficacy was a secondary objective.

Methods:
This phase II, multicentre, single-arm, open-label, 8-week trial included patients aged 12–17 years with moderate-to-very severe scalp psoriasis according to Investigator's Global Assessment (IGA) (≥ 10% of the scalp area affected).

Results:
Seventy-eight patients received treatment. Twenty-seven patients (35%) reported a total of 64 adverse events (AEs); most were mild (33/64) or moderate (22/64) in severity and there were no serious AEs. No cases of hypercalcaemia were reported, and the mean changes from baseline to end of treatment in albumin-corrected serum calcium (0·00 mmol L−1), 24-h urinary calcium excretion (−0·03 mmol per 24 h) and urinary calcium-to-creatinine ratio (−0·12 mmol g−1) were not considered clinically relevant. At the end of treatment 66 patients (85%) were clear or almost clear according to IGA. There was an 80% improvement in mean Total Sign Score from baseline to end of treatment. In total, at the end of treatment, 87% of patients rated their scalp psoriasis as clear or very mild, and 75 (96%) had no or mild pruritus compared with 14 (18%) at baseline.

Conclusions:

Once-daily calcipotriol plus betamethasone dipropionate gel is well tolerated and efficacious for scalp psoriasis in adolescents.

Source: NO LINKS ALLOWED

Dovobet And Dovonex (What's the difference ?)

[jiml]

Though not mentioning the products by name in the study I assume it is about treating adolescent scalp psoriasis with Dovobet (Daivobet) and Dovonex (Daivonex) as it was sponsored by LEO Pharma.

Quote:

---

Objectives:
The primary objective was to assess the safety of once-daily application of fixed-combination calcipotriol plus betamethasone dipropionate gel in adolescent scalp psoriasis. Assessment of efficacy was a secondary objective.

Methods:
This phase II, multicentre, single-arm, open-label, 8-week trial included patients aged 12–17 years with moderate-to-very severe scalp psoriasis according to Investigator's Global Assessment (IGA) (≥ 10% of the scalp area affected).

Results:
Seventy-eight patients received treatment. Twenty-seven patients (35%) reported a total of 64 adverse events (AEs); most were mild (33/64) or moderate (22/64) in severity and there were no serious AEs. No cases of hypercalcaemia were reported, and the mean changes from baseline to end of treatment in albumin-corrected serum calcium (0·00 mmol L−1), 24-h urinary calcium excretion (−0·03 mmol per 24 h) and urinary calcium-to-creatinine ratio (−0·12 mmol g−1) were not considered clinically relevant. At the end of treatment 66 patients (85%) were clear or almost clear according to IGA. There was an 80% improvement in mean Total Sign Score from baseline to end of treatment. In total, at the end of treatment, 87% of patients rated their scalp psoriasis as clear or very mild, and 75 (96%) had no or mild pruritus compared with 14 (18%) at baseline.

Conclusions:

Once-daily calcipotriol plus betamethasone dipropionate gel is well tolerated and efficacious for scalp psoriasis in adolescents.

Source: NO LINKS ALLOWED

Dovobet And Dovonex (What's the difference ?)

It's the Dovobet gel they were testing not the Dovonex big difference but a good trial and as long as the Dovobet is used for short spells I'm sure it is fine but the trouble is if it works and the psoriasis comes back .... Which it will .... People will, as I used to go to the doctor for a repeat prescription.... So what about long term effects of steroid gels on the scalp that would be an interesting read

I know GP practices in many cases just tick a box and you can get another six repeats before renewing....... I used to do this all the time blindly applying not just the gel but the ointments all over ..... Who can blame the sufferer if the gel works for going back for more. ....it's when patients keep presenting they should call a halt and get onto something less damaging

[Fred]

It's the Dovobet gel they were testing not the Dovonex

I put Dovonex in too as it said "combination calcipotriol plus betamethasone dipropionate gel"

Dovonex is Calcipotriol based.

Dovobet is Betamethasone based.

So I read it as a study of using both together.

Ohhhhhhhhhhhh now I'm confused.

[jiml]

Fred I'm reading from the Dovobet gel label
One gram of gel contains 50 micrograms of calcipotriol ( as monohydrate) and 0.5 mg of bethamethasone ( as dipropionate)
If that helps

[Fred]

Fred I'm reading from the Dovobet gel label
One gram of gel contains 50 micrograms of calcipotriol ( as monohydrate) and 0.5 mg of bethamethasone ( as dipropionate)
If that helps

Yes I'm reading it here Dovobet And Dovonex (What's the difference ?) but I'm still reading the study as using both, the study itself doesn't mention Dovobet and Dovonex but I'm reading this part

Quote:

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once-daily application of fixed-combination calcipotriol plus betamethasone dipropionate gel

And the words "Fixed-Combination" and the use of the word "Plus" makes me thinks they are talking about both.

I see your point Jim, but it aint helping me understand if they are talking about one or both. Be so simple if they told us the names the patient knows and understand, and this proves like you said and like the Dovobet And Dovonex (What's the difference ?) states There is a difference and it's important

I'll leave you thinking of a way of explaining it to me in Fred talk.

[jiml]

Quote:

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Fred I'm reading from the Dovobet gel label
One gram of gel contains 50 micrograms of calcipotriol ( as monohydrate) and 0.5 mg of bethamethasone ( as dipropionate)

If you change my words to read as follows


One gram of gel contains 50 micrograms of calcipotriol ( as monohydrate) plus 0.5 mg of bethamethasone ( as dipropionate)

Then you have dermovate gel
there is no point in using both Dovobet and Dovonex together
Mainly because I don't think Dovonex does a gel

[Fred]

Jim I thik it's best I leave this thread and let our readers make their own minds up, or maybe someone else will comment.

But it's Friday night, I got my wine, and I have business in Off Topic.