Bath-Psoralen & Ultraviolet A for Psoriasis

[Fred]

Bath-PUVA therapy involved immersion in water at 37°C containing 8-methoxypsoralen bath salts at a concentration of 0.0001% for 15 min, followed by immediate ultraviolet A (UVA) irradiation.

Quote:

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Background/Purpose:
While biologics and small-molecule inhibitors are first-line systemic treatments for psoriasis, phototherapy remains an alternative for patients unable to access these treatments because of medical or financial constraints. Narrow-band ultraviolet B (NB-UVB) is effective for localized psoriasis but less so for extensive disease. To address this limitation, bathwater delivery of psoralen plus ultraviolet A (bath-PUVA) was introduced in 2004. This study evaluates the efficacy, safety, and patient characteristics associated with bath-PUVA therapy in a large cohort.

Methods:
This retrospective analysis included 229 patients (180 males, 49 females) treated with bath-PUVA from 2004 to September 2021. Baseline characteristics and treatment outcomes were assessed using the psoriasis area and severity index (PASI). Statistical analyses examined relationships between treatment outcomes and factors, including baseline PASI, body mass index (BMI), and smoking status.

Results:
The mean baseline PASI score was 24.9. Bath-PUVA achieved PASI 75 in 80.4% of patients, PASI 90 in 44.1%, and PASI 100 in 2.6%, with efficacy comparable to biologics. Patients achieving PASI 90 had significantly higher baseline PASI scores (p = 0.005), while the number of irradiations required did not differ (p = 0.692). Higher baseline PASI scores correlated with elevated BMI (p = 0.002), but BMI did not influence improvement rates (p = 0.094). Smokers had significantly higher baseline PASI scores (p = 0.004) compared with non-smokers, yet smoking status did not affect improvement rates (p = 0.862).

Conclusion:
Bath-PUVA demonstrates efficacy comparable with biologics for psoriasis, regardless of BMI or smoking status. This analysis supports its use as an effective and accessible treatment option for patients with extensive disease.

Source: onlinelibrary.wiley.com

*Funding: Early view funding unknown.

[Caroline]

I wonder how often this treatment can be used before you are on your maximum UVA level and the risk of cancer becomes too high.

In my view, almost all phototherapy based on PUVA is a dead end street.

Yes, it helps, but at what cost?


I checked a little on the network. It seems the drawback of carcinogenic risks is deliberately avoided in this abstract.
Bath-PUVA is not different from PUVA.
So 150-250 sessions are the max. And continuous checking is necessary.

If you would follow this treatment it is good to realise that the damage done is cumulative .
That means that if you reach your max, then you have to be very careful going in the sun, for the rest of your life.

No thanks….. then I prefer a biologic or my other favorite treatment….

[Fred]

No thanks….. then I prefer a biologic or my other favorite treatment….

I agree it's just a cheap way of preventing the inevitable, I very much doubt it will rid anyone of psoriasis long term and you just can't keep using it.

[mataribot]

They’re adding stuff to list of things they can waste your time with.

[Fred]

They’re adding stuff to list of things they can waste your time with.

Yep