Psoriasis and uveitis

[Fred]

This study evaluated the risk of first occurrence and recurrence of uveitis in patients with psoriasis in the Korean population.

Quote:

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Background:
Evidence for the association between psoriasis and uveitis according to the severity of psoriasis including psoriatic arthritis (PsA) and type of uveitis is lacking, and there are no data on the frequency or timing of recurrence of uveitis in patients with psoriasis.

Objectives:
We aimed to evaluate the risk of first-occurrence and recurrence of uveitis in patients with psoriasis in the Korean population. We further evaluated the risk of uveitis according to the severity of psoriasis, comorbidity of PsA, and location of uveitis.

Methods:
In a nationwide retrospective cohort study, we compared 317,940 adult patients who had psoriasis with 635,880 matched controls. Incidence rates (IRs) and estimated IR ratios of the first occurrence and recurrence of uveitis were calculated using survival analysis and Poisson regression, respectively.

Results:
The rate of uveitis incidence and uveitis recurrence in patients with psoriasis were 1.18 and 2.31 per 1,000 person-years, respectively. Compared with the controls, the IR ratios of development and recurrence of uveitis in patients with psoriasis were 1.14 (95% CI 1.08, 1.2) and 1.16 (95% CI 1.12, 1.21), respectively. The recurrence rate of uveitis was highest within 3 years after the onset of psoriasis. The corresponding IR ratios for uveitis recurrence in patients with mild psoriasis, severe psoriasis, and PsA were 1.11 (1.06, 1.16), 1.24 (1.16, 1.33), and 1.49 (1.31, 1.7), respectively. Patients with psoriasis had an increased risk of recurrence of anterior uveitis, and patients with both psoriasis and PsA had an increased risk of recurrence of both anterior and pan-uveitis.

Conclusions:
Patients with psoriasis had a higher risk of both development and recurrence of uveitis, especially with severe psoriasis and PsA. The timing of uveitis recurrence was related to the onset of psoriasis, and patients who had psoriasis with PsA had an increased risk of vision-threatening pan-uveitis.

Source: onlinelibrary.wiley.com

*Early view funding unknown. 

[Caroline]

South-Korea, I think they have done this research in, has 51 million inhabitants.
We, Netherlands, have 17 million inhabitants and in our country there are about 400.000 people with psoriasis.
Assuming the occurance in both countries is about the same, then 51/17 * 400.000 = 1.200.000,
1.2 million have psoriasis/psa
It is handling about adults… sooo, well perhaps there are 1 million adults.

They succeeded in incorporating 317.940 patients in that study. That is about 1/3 of the sufferers..

I don’t know about you, but that is a stunning number, and in my view hard to believe.
Mostly because I know that in the Netherlands, around 3/4 of the sufferers is simply treated by the GP’s with simple cremes…who often even hardly know that they have Psoriasis until it becomes worse.

[Fred]

South-Korea, I think they have done this research in, has 51 million inhabitants.
We, Netherlands, have 17 million inhabitants and in our country there are about 400.000 people with psoriasis.
Assuming the occurance in both countries is about the same, then 51/17 * 400.000 = 1.200.000,
1.2 million have psoriasis/psa
It is handling about adults… sooo, well perhaps there are 1 million adults.

They succeeded in incorporating 317.940 patients in that study. That is about 1/3 of the sufferers..

I don’t know about you, but that is a stunning number, and in my view hard to believe.
Mostly because I know that in the Netherlands, around 3/4 of the sufferers is simply treated by the GP’s with simple cremes…who often even hardly know that they have Psoriasis until it becomes worse.

I hate maths.

[Caroline]

South-Korea, I think they have done this research in, has 51 million inhabitants.
We, Netherlands, have 17 million inhabitants and in our country there are about 400.000 people with psoriasis.
Assuming the occurance in both countries is about the same, then 51/17 * 400.000 = 1.200.000,
1.2 million have psoriasis/psa
It is handling about adults… sooo, well perhaps there are 1 million adults.

They succeeded in incorporating 317.940 patients in that study. That is about 1/3 of the sufferers..

I don’t know about you, but that is a stunning number, and in my view hard to believe.
Mostly because I know that in the Netherlands, around 3/4 of the sufferers is simply treated by the GP’s with simple cremes…who often even hardly know that they have Psoriasis until it becomes worse.

I hate maths. 

Is this math? I think it is calculus, I am only counting.
Just like the arithmetic of three times twentythree, where you don’t need mathematics for.

[Fred]

South-Korea, I think they have done this research in, has 51 million inhabitants.
We, Netherlands, have 17 million inhabitants and in our country there are about 400.000 people with psoriasis.
Assuming the occurance in both countries is about the same, then 51/17 * 400.000 = 1.200.000,
1.2 million have psoriasis/psa
It is handling about adults… sooo, well perhaps there are 1 million adults.

They succeeded in incorporating 317.940 patients in that study. That is about 1/3 of the sufferers..

I don’t know about you, but that is a stunning number, and in my view hard to believe.
Mostly because I know that in the Netherlands, around 3/4 of the sufferers is simply treated by the GP’s with simple cremes…who often even hardly know that they have Psoriasis until it becomes worse.

I hate maths. 

Is this math? I think it is calculus, I am only counting.
Just like the arithmetic of three times twentythree, where you don’t need mathematics for. 

[Forest Walker]

I appreciate Caroline's ability to think through these things.  I am terrible at math.  Uveitis is also something people with Crohn's Disease are told about.  Perhaps it's more associated with an autoimmune disease process in general.

[Caroline]

I appreciate Caroline's ability to think through these things.  I am terrible at math.  Uveitis is also something people with Crohn's Disease are told about.  Perhaps it's more associated with an autoimmune disease process in general.

That could be very well possible, that it is not only limited to psoriasis, but to many other inflammatory diseases.

[Kat]

It's an interesting read. A lot of which I don't understand.



And maybe it's a language thing, but 3 times 23 is still math!  One plus One is considered math.

And calculus is.... math. 

And the rest of this is science............ I'm out. 

[Fred]

It's an interesting read.  A lot of which I don't understand.



And maybe it's a language thing, but 3 times 23 is still math!  One plus One is considered math.

And calculus is.... math. 

And the rest of this is science............ I'm out. 

[Caroline]

I have always thought that + - * /. Are calculus.

And that roots, sinus, cosinus, differential and intergration stuff was real mathematics, together with complex formula’s.