Caroline I'm not sure if you have seen or posted about this on here, but I'm sure you will find it interesting.

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Background: 
Fumaric acid esters (FAE) are used as an effective and safe oral treatment for plaque psoriasis in adult patients, but little is known about their efficacy and safety in children with psoriasis.

Objectives: 
To assess the effectiveness and safety of FAE in the treatment of paediatric psoriasis.

Methods: 
This is a retrospective analysis of 14 paediatric patients with psoriasis (age < 18 years) treated with FAE between 2004 and 2012 at several Dutch university and regional clinics. Patients were identified through databases or registries.

Results: 
The median age at the start of FAE treatment was 15 years (range 8–17 years). The median duration of FAE treatment was 10 months (range 1–80 months), and the median maintenance dosage per day was 360 mg dimethylfumarate (range 240–600 mg). Five patients (36%) achieved a complete clearance of their psoriasis, one patient (7%) had a good improvement, three patients (21%) had a partial response and five patients (36%) were nonresponders. FAE treatment was well tolerated, but two patients (14%) discontinued FAE, one with severe diarrhoea and one with flushes. Five patients (36%) had transient, slightly abnormal laboratory values of liver-function tests or leucocytes that did not necessitate FAE dosage reduction or treatment discontinuation. No serious adverse events occurred.

Conclusions: 
In this retrospective case series FAE seemed to be an effective and safe treatment for children with psoriasis. FAE may be an attractive therapeutic alternative to the currently used systemic immunosuppressive agents for paediatric patients with psoriasis. Further studies are needed to evaluate the suitability of FAE in paediatric psoriasis.

Source: NO LINKS ALLOWED

A very interesting article I hope they do more research into Fumeric acid esters on children, as I know from getting psoriasis age 17 the total despair you experience, I can only imagine the desparate feelings children would experience having to wear it to school.
I hope that it will be prescribed to more as it has proved effective although not a large test I think it should be expanded,

Another question. I was chatting to a younger lady with psoriasis and she said her doctor would not put her on tablets whilst she was of child bearing age.
Are their complications with pregnant woman taking Fumeric acid esters in any form ?

(Mon-20-01-2014, 12:35 PM)jiml Wrote: Another question. I was chatting to a younger lady with psoriasis and she said her doctor would not put her on tablets whilst she was of child bearing age.
Are their complications with pregnant woman taking Fumeric acid esters in any form ?

Caroline may know more, but I did get the following info from The British Association Of Dermatologists.

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Do fumaric acid esters affect fertility or pregnancy?

FAE (fumaric acid esters) do not affect fertility. Pregnancy should be avoided, so contraception is advised for women taking FAE. If you are planning a family, or if you become pregnant whilst taking FAE, you should contact your doctor as soon as possible. You should not breast feed if you are taking FAE. For men taking FAE (if the treatment is considered essential), it may be possible to continue them while trying to have a family, but this should always be discussed first with your dermatologist.

(Mon-20-01-2014, 13:22 PM)Fred Wrote:

(Mon-20-01-2014, 12:35 PM)jiml Wrote: Another question. I was chatting to a younger lady with psoriasis and she said her doctor would not put her on tablets whilst she was of child bearing age.
Are their complications with pregnant woman taking Fumeric acid esters in any form ?

Caroline may know more, but I did get the following info from The British Association Of Dermatologists.

Quote:

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Do fumaric acid esters affect fertility or pregnancy?

FAE (fumaric acid esters) do not affect fertility. Pregnancy should be avoided, so contraception is advised for women taking FAE. If you are planning a family, or if you become pregnant whilst taking FAE, you should contact your doctor as soon as possible. You should not breast feed if you are taking FAE. For men taking FAE (if the treatment is considered essential), it may be possible to continue them while trying to have a family, but this should always be discussed first with your dermatologist.

As far as I know it is not good to use DMF, which is a fumaric acid ester (!), when you are planning to get pregnant, at least my doctor (no dermatologist) advised that. For the practicing it makes no difference.

(Mon-20-01-2014, 15:56 PM)Caroline Wrote: For the practicing it makes no difference.