Biological Treatments For Psoriasis

[Fred]

Note: Orencia is only used for psoriatic arthritis.

Orencia: (generic name abatacept) For adult patients with psoriatic arthritis, Orencia may be administered as an intravenous infusion (IV) or a subcutaneous (SC) injection. Orencia can be used with or without non-biologic DMARDs.
Intravenous Dosing Regimen:
Orencia should be administered as a 30-minute intravenous infusion utilizing the weight range-based dosing. Following the  initial intravenous administration, an intravenous infusion should be given at 2 and 4 weeks after the first infusion and every 4 weeks thereafter.
Subcutaneous Dosing Regimen:
Orncia 125 mg should be administered by subcutaneous injection once weekly without the need for an intravenous loading dose. Patients switching from Orencia intravenous therapy to subcutaneous administration should administer the first subcutaneous dose instead of the next scheduled intravenous dose.
Treatment will usually be stopped if there is no improvement after 12 weeks.

Patients should be checked for tuberculosis (TB) before taking Orencia and you should have regular blood tests.

Who should not take Orencia?
*People with active serious infections, history of recurrent infections.
*Children - Orencia is not aproved for under 18s with psoriatic arthritis
*You should consult your specialist if you are pregnant, planning a baby, or breast feeding

What should I watch for AFTER starting Orencia?
*Infections.
*Allergic Reactions.
*Fevers sweats chills, muscle aches, coughs, shortness of breath, blood in phlegm.
*Weight loss.
*Warm, red, or painful skin or sores on your body
*Diarrhoea or stomach pain, burning when you urinate or urinate more often than normal

The most common side effects of Orencia include: Headache, Sore throat, Upper respiratory tract infection, Nausea.

orencia.com

Tips on using the bio treatments: Biological Treatments For Psoriasis

[Fred]

Kyntheum in Europe / Siliq in the USA: (generic name brodalumab)

Siliq / Kyntheum: Is taken by injection under the skin and after tuition the patient can do this themselves, see first post in this thread for some tips. The recommended starting dose of Silq / Kyntheum is 210 mg once a week for the first 3 weeks with a maintenance dose of 210 mg every 2 weeks. Treatment will usually be stopped if there is no improvement after 12 - 16 weeks.

Patients should be checked for tuberculosis (TB) before taking Siliq / Kyntheum and you should have regular blood tests.

Who should not take Siliq / Kyntheum?

• People with active serious infections, history of recurrent infections.
  
• Children - Siliq / Kyntheum is not aproved for under 18s.
  
• You should consult your specialist if you are pregnant, planning a baby, or breast feeding.
  
• People with Crohn’s disease.
  
• Those that have had suicidal thoughts.
  

What should I watch for AFTER starting Siliq / Kyntheum?

• Infections.
  
• Allergic Reactions.
  
• Fevers sweats chills, muscle aches, coughs, shortness of breath, blood in phlegm.
  
• Weight loss.
  
• Warm, red, or painful skin or sores on your body
  
• Diarrhoea or stomach pain, burning when you urinate or urinate more often than normal
  

The most common side effects of Siliq / Kyntheum include: Joint pain, Headache, Tredness, Diarrhea, Mouth or throat pain, Nausea, Muscle pain, Injection site reactions, Llu (influenza), low white blood count (neutropenia), and Fungal infections of the skin.

*Note: There have been reports of siliq / Kyntheum and Suicidal Thoughts so this information has to be included with the patient information.

Quote:

---

Suicidal thoughts or behavior have happened in some people treated with SILIQ. Some people have ended their own lives. Your risk of suicidal thoughts  and  behavior  may  be  increased  if  you  have  a  history  of  suicidal  thoughts  or  depression.  It  is  not  known  if  SILIQ  causes suicidal thoughts or behavior. Get medical help right away if you or your caregiver notice any of the following symptoms:

• New or worsening depression or anxiety
  
• Thoughts of suicide, dying, or hurting yourself
  
• Changes in behavior or mood
  
• Acting on dangerous impulses
  
• Attempt to commit suicide  
  

siliq.com

Tips on using the bio treatments: Biological Treatments For Psoriasis

[Fred]

Ilumetri in Europe / Ilumya in the USA: (generic name tildrakizumab)

Ilumya  / Ilumetri: Is taken by injection under the skin and after tuition the patient can do this themselves, see first post in this thread for some tips. The recommended starting dose of Ilumya  / Ilumetri is 100 mg* at week 0 and week 4 with a maintenance dose of 100 mg* every 12 weeks. Treatment will usually be stopped if there is no improvement after 12 - 16 weeks.

*Note: A double dose of 200 mg may be recommended for those over 90 Kg or with a very high PASI score.

Patients should be checked for tuberculosis (TB) before taking Ilumya  / Ilumetri and you should have regular blood tests.

Who should not take Ilumya  / Ilumetri?

• If you have an infection that does not go away or that keeps coming back.
  
• If you have TB or have been in close contact with someone with TB.
  
• If you have recently received or are scheduled to receive a vaccine (immunization). You should avoid receiving live vaccines.
  
• If you are pregnant or plan to become pregnant. It is not known if Ilumya  / Ilumetri can harm your unborn baby.
  
• If you are breastfeeding or plan to breastfeed. It is not known if Ilumya  / Ilumetri passes into your breast milk.
  
• Ilumya  / Ilumetri is not approved for under 18s.
  

What should I watch for after starting Ilumya  / Ilumetri?

• Fever, sweats, chills, muscle aches, weight loss, cough.
  
• Warm, red, or painful skin or sores on your body different from your psoriasis.
  
• Diarrhea or stomach pain.
  
• Shortness of breath.
  
• Burning when you urinate or urinating more often than normal.
  
• Blood in your phlegm (mucus).
  

The most common side effects of Ilumya  / Ilumetri include: Upper respiratory infections, injection site reactions and diarrhoea.

ilumya.com

Tips on using the bio treatments: Biological Treatments For Psoriasis

[Fred]

Skyrizi: (generic name risankizumab) Is taken by injection under the skin and after tuition the patient can do this themselves, see first post in this thread for some tips. The recommended dose is 150 mg (two 75 mg injections) administered by subcutaneous injection at Week 0, Week 4, and every 12 weeks thereafter.

Patients should be checked for tuberculosis (TB) before taking Skyrizi and you should have regular blood tests.

Who should not take Skyrizi?
*People with active serious infections, history of recurrent infections.
*Children - Skyrizi is not aproved for under 18s.
*You should consult your specialist if you are pregnant, planning a baby, or breast feeding

What should I watch for AFTER starting Skyrizi?
*Infections.
*Allergic Reactions.
*Fevers sweats chills, muscle aches, coughs, shortness of breath, blood in phlegm.
*Weight loss.
*Warm, red, or painful skin or sores on your body
*Diarrhoea or stomach pain, burning when you urinate or urinate more often than normal

The most common side effects of Skyrizi include: Upper respiratory infections, headache, fatigue, injection site reactions, and tinea infections.

skyrizihcp.com

Tips on using the bio treatments: Biological Treatments For Psoriasis

[Fred]

Bimzelx: (generic name bimekizumab) Is taken by injection under the skin and after tuition the patient can do this themselves, see first post in this thread for some tips. The recommended dose is 320 mg (two injections of 160 mg each) at week 0, 4, 8, 12, 16 and every 8 weeks thereafter.

Patients should be checked for tuberculosis (TB) before taking Bimzelx and you should have regular blood tests.

Who should not take Bimzelx?
*People with active serious infections, history of recurrent infections.
*Bimekizumab is not recommended in patients with inflammatory bowel disease.
*Children - Bimzelx is not aproved for under 18s.
*You should consult your specialist if you are pregnant, planning a baby, or breast feeding

What should I watch for AFTER starting Bimzelx?
*fever, flu-like symptoms, night sweats 
*feeling tired or short of breath, cough which will not go away 
*warm, red and painful skin, or a painful skin rash with blisters
*upper respiratory infections with symptoms such as sore throat and stuffy nose
*thrush in the mouth or throat with symptoms such as white or yellow patches; red or sore mouth and pain with swallowing
*fungal infection of the skin, such as athlete’s foot between the toes
*ear infections
*cold sores (herpes simplex infections)
*stomach flu (gastroenteritis)
*inflamed hair follicles which may look like pimples
*headache
*itchy, dry skin or an eczema-like rash sometimes with swollen and reddened skin (dermatitis) 
*acne
*redness, pain or swelling at the site of injection 
*feeling tired

ucbconnect.com

Tips on using the bio treatments: Biological Treatments For Psoriasis

[Fred]

Spevigo (spesolimab) Is given by infusion in the vein by a professional and takes around 90 minutes. Usually given only once but an additional dose  may be needed after 1 week.

Patients should be checked for tuberculosis (TB) before taking Spevigo.

Who should not take Spevigo

• If you have an infection that keeps returning or does not go away.
  
• Recently received or are scheduled to receive a vaccine. *You should not receive live vaccines after treatment with Spevigo.
  

What should I watch for AFTER having Spevigo

• fevers, chills, or sweats
  
• muscle aches
  
• cough
  
• shortness of breath
  
• blood in your phlegm (mucus)
  
• burning when you urinate
  
• urinating more often than normal
  

The most common side effects are tiredness or weakness; nausea, vomiting; headache; itching or itchy bumps; bruising or blood under the skin where the injection was given; or pain or burning when you urinate.

spevigo.com

Tips on using the bio treatments: Biological Treatments For Psoriasis