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+--- Thread: Methotrexate no better than Placebo for Psoriatic Arhtritis (/thread-228.html)
Methotrexate no better than Placebo for Psoriatic Arhtritis - Fred - Fri-21-10-2011
Methotrexate is not a disease-modifying antirheumatic drug in psoriatic arthritis, despite how well it works in psoriasis, according to Dr. Christopher T. Ritchlin.
Methotrexate is the most widely used drug in the world for psoriatic arthritis (PsA), based on almost no supporting evidence. There have been only two published double-blind, randomized, controlled trials of methotrexate in PsA done over the last 20 years, and both were underpowered and used a low dose of methotrexate (10 mg/week), said Dr. Ritchlin, professor of medicine and director of the clinical immunology research centre at the University of Rochester (N.Y.).
A still-unpublished study that was presented at the annual meeting of the American College of Rheumatology in 2010 showed that methotrexate was not more effective than placebo in PsA The study involved 221 patients who were given 15 mg/week of methotrexate or placebo for 6 months. About 65% of subjects in each group dropped out. The primary outcome measure was the psoriatic arthritis response criteria (PsARC), which most rheumatologists do not think is a good outcome measure, Dr. Ritchlin said at the Perspectives in Rheumatic Diseases 2011 meeting.
At the end of 3 and 6 months of the study, there were no differences between methotrexate and placebo on the PsARC, the ACR 20 (the American College of Rheumatology scale based on a 20% improvement in certain parameters), the DAS28 (Disease Activity Score based on a 28-joint count), a sensitive joint count, a tender joint count, and the C-reactive protein level/erythrocyte sedimentation rates. Only the patient and physician global scores and the skin score showed significant improvement in the methotrexate group.
Indirect data supporting the inefficacy of methotrexate come from NOR-DMARD. These data show that 6 months of treatment with a tumor necrosis factor inhibitor (146 patients) had significantly greater beneficial effects on patients with PsA than did methotrexate.
The propensity toward liver disease is another reason not to use methotrexate in patients with PsA, said Dr. Ritchlin at the meeting, which was sponsored by Skin Disease Education Foundation. Methotrexate is hepatotoxic. Data on the findings of 169 liver biopsies that were done on 71 patients with psoriasis showed that methotrexate significantly increased the risk for stage 3 or 4 fibrosis.
RE: Methotrexate no better than Placebo for Psoriatic Arhtritis - Caroline - Thu-28-08-2014
Fred,
Do you know the exact research article of this post?
RE: Methotrexate no better than Placebo for Psoriatic Arhtritis - Fred - Thu-28-08-2014
(Thu-28-08-2014, 16:24 PM)Caroline Wrote: Fred,
Do you know the exact research article of this post?
Looks like I got it from here: LINK REMOVED
RE: Methotrexate no better than Placebo for Psoriatic Arhtritis - Caroline - Thu-28-08-2014
(Thu-28-08-2014, 16:43 PM)Fred Wrote:(Thu-28-08-2014, 16:24 PM)Caroline Wrote: Fred,
Do you know the exact research article of this post?
Looks like I got it from here:
Thanks Fred, I got into a discussion with someone who said the opposite...
You can guess the tone of this conversation
tiger like. 
RE: Methotrexate no better than Placebo for Psoriatic Arhtritis - Fred - Thu-28-08-2014
(Thu-28-08-2014, 20:33 PM)Caroline Wrote:(Thu-28-08-2014, 16:43 PM)Fred Wrote:(Thu-28-08-2014, 16:24 PM)Caroline Wrote: Fred,
Do you know the exact research article of this post?
Looks like I got it from here:
Thanks Fred, I got into a discussion with someone who said the opposite...
You can guess the tone of this conversation
You're welcome, looking at the article I think a little more has been added since I posted it. But well done Tiger can I class this as another agreement between us.
RE: Methotrexate no better than Placebo for Psoriatic Arhtritis - Caroline - Thu-28-08-2014
(Thu-28-08-2014, 20:38 PM)Fred Wrote:(Thu-28-08-2014, 20:33 PM)Caroline Wrote:(Thu-28-08-2014, 16:43 PM)Fred Wrote:(Thu-28-08-2014, 16:24 PM)Caroline Wrote: Fred,
Do you know the exact research article of this post?
Looks like I got it from here:
Thanks Fred, I got into a discussion with someone who said the opposite...
You can guess the tone of this conversation
You're welcome, looking at the article I think a little more has been added since I posted it. But well done Tiger can I class this as another agreement between us.
Ehmmmm, what is the agreement then?
RE: Methotrexate no better than Placebo for Psoriatic Arhtritis - Fred - Thu-28-08-2014
(Thu-28-08-2014, 20:40 PM)Caroline Wrote:(Thu-28-08-2014, 20:38 PM)Fred Wrote:(Thu-28-08-2014, 20:33 PM)Caroline Wrote:(Thu-28-08-2014, 16:43 PM)Fred Wrote:(Thu-28-08-2014, 16:24 PM)Caroline Wrote: Fred,
Do you know the exact research article of this post?
Looks like I got it from here:
Thanks Fred, I got into a discussion with someone who said the opposite...
You can guess the tone of this conversation
You're welcome, looking at the article I think a little more has been added since I posted it. But well done Tiger can I class this as another agreement between us.
Ehmmmm, what is the agreement then?
We both agree Methotrexate is a poison that should be banned in it's use for treating psoriasis or psoriatic arthritis.
RE: Methotrexate no better than Placebo for Psoriatic Arhtritis - Caroline - Thu-28-08-2014
(Thu-28-08-2014, 20:45 PM)Fred Wrote:(Thu-28-08-2014, 20:40 PM)Caroline Wrote:(Thu-28-08-2014, 20:38 PM)Fred Wrote:(Thu-28-08-2014, 20:33 PM)Caroline Wrote:(Thu-28-08-2014, 16:43 PM)Fred Wrote: Looks like I got it from here:
Thanks Fred, I got into a discussion with someone who said the opposite...
You can guess the tone of this conversation
You're welcome, looking at the article I think a little more has been added since I posted it. But well done Tiger can I class this as another agreement between us.
Ehmmmm, what is the agreement then?
We both agree Methotrexate is a poison that should be banned in it's use for treating psoriasis or psoriatic arthritis.
Ok....
I agree that it's is an agreement.
RE: Methotrexate no better than Placebo for Psoriatic Arhtritis - Fred - Thu-28-08-2014
(Thu-28-08-2014, 20:49 PM)Caroline Wrote:(Thu-28-08-2014, 20:45 PM)Fred Wrote:(Thu-28-08-2014, 20:40 PM)Caroline Wrote:(Thu-28-08-2014, 20:38 PM)Fred Wrote:(Thu-28-08-2014, 20:33 PM)Caroline Wrote: Thanks Fred, I got into a discussion with someone who said the opposite...
You can guess the tone of this conversation
You're welcome, looking at the article I think a little more has been added since I posted it. But well done Tiger can I class this as another agreement between us.
Ehmmmm, what is the agreement then?
We both agree Methotrexate is a poison that should be banned in it's use for treating psoriasis or psoriatic arthritis.
Ok....
I agree that it's is an agreement.
Nice, I've chalked it up.